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Postdoctoral Research Associate: Synthesis and Characterization of Deuterated
Location:
Oak Ridge, TN
Description:
Requisition Id11866 Overview: As a U.S. Department of Energy (DOE) Office of Science national laboratory, ORNL has an extraordinary 80:year history of solving the nation's biggest problems. With a dedicated and creative staff of over 6,000 people, ORNL's decadal vision for diversity, equity, inclusion, and accessibility (DEIA) is to cultivate an environment and practices that foster diversity in ideas and in the people across the organization, as well as to ensure ORNL is recognized as a workplace of choice. These elements are critical for enabling the execution of ORNL's broader mission to accelerate scientific discoveries and their translation into energy, environment, and security solutions for the nation. We are seeking a Postdoctoral Research Associate with a strong background in organic chemistry for synthesis and characterization of deuterated lipids to study the structural properties of lipid nanoparticles (LNPs). In this role, you will work as part of an interdisciplinary team from different DOE National Laboratories and partner Universities that is funded by the DOE Biopreparedness Research Virtual Environment (BRaVE) initiative. You will contribute to a project that aims to develop an integrated platform for rapid characterization and analysis of LNPs to aid in RNA vaccine design. You will be responsible for synthesis of non:deuterated and/or deuterated lipids to support X:ray and neutron scattering measurements to provide insights into the structure of LPNs. You will have the opportunity to work with a multidisciplinary team comprised of specialists in organic synthesis, structural biology, X:ray and neutron scattering, and computation. Our synthesis laboratory, located in the Center for Nanophase Materials Sciences, is equipped with state:of:the:art instrumentation including continuous flow reactors, nuclear magnetic resonance (NMR) spectroscopy, gas chromatography mass spectrometry (GCMS), etc., for synthesis and characterization. As part of our research team, you will be responsible for delivering high impact research results to advance the field of LPN research. You will design and execute laboratory experiments, analyze data, and publish results for the scientific community. Major Duties/Responsibilities: :Design synthetic routes for deuterated molecules including ionizable lipids to meet project goals:Develop novel methods for deuteration of related biomolecules and biomacromolecules:Use a variety of methods to characterize and evaluate newly synthesized molecules (e.g., NMR spectroscopy, GCMS, HPLC, UV:vis spectroscopy, and single:crystal X:ray diffraction):Participate in project planning and execution:Present and report research results at group meetings and national conferences:Publish scientific results in high:impact peer:reviewed journals in a timely manner:Ensure compliance with environment, safety, health, and quality program requirements:Maintain strong dedication to the implementation and perpetuation of values and ethics:Deliver ORNL's mission by aligning behaviors, priorities, and interactions with our core values of Impact, Integrity, Teamwork, Safety, and Service. Promote diversity, equity, inclusion, and accessibility by fostering a respectful workplace : in how we treat one another, work together, and measure success Basic Qualifications: :A PhD in Chemistry, Biochemistry, or a related field completed within the last 5 years Preferred Qualifications: :Hands:on experience in synthesis and characterization of deuterated or other isotopic molecules :A strong background in multi:step synthesis of lipids or other organic molecules including experience with isolation/purification techniques (e.g., column chromatography, crystallization, HPLC, flash column, etc.), and characterization methods (e.g., NMR, UV:vis, and FT:IR spectroscopies, mass spectrometry, etc.):Experience in synthesis and characterizatio
Posted:
May 17 on Tip Top Job
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More About this Listing: Postdoctoral Research Associate: Synthesis and Characterization of Deuterated
Postdoctoral Research Associate: Synthesis and Characterization of Deuterated is a Research Research Associate Job located in Oak Ridge TN. Find other listings like Postdoctoral Research Associate: Synthesis and Characterization of Deuterated by searching Oodle for Research Research Associate Jobs.
Postdoctoral Research Associate: Synthesis and Characterization of Deuterated is a Research Research Associate Job located in Oak Ridge TN. Find other listings like Postdoctoral Research Associate: Synthesis and Characterization of Deuterated by searching Oodle for Research Research Associate Jobs.